翻訳と辞書 Words near each other ・ Gut flora ・ Gut Island ・ Gut loading ・ Gut Muri ・ Gut Records ・ Gut River ・ Gut River (Crișul Alb) ・ Gut Sorkheh ・ Gut Stomp ・ Gut Symmetries ・ Gut the Van ・ Gut Weißenhaus ・ Gut Wrench ・ Gut-1 RNA motif ・ Gut-associated lymphoid tissue ・ Gut-specific homing ・ Guta ・ Guta District ・ Guta language ・ Guta raJehovah ・ Guta Stresser ・ Gutach ・ Gutach (Kinzig) ・ Gutach (Schwarzwaldbahn) ・ Gutach im Breisgau ・ Gutaguddi ・ Gutai group ・ Gutak coat of arms ・ Gutalac, Zamboanga del Norte ・ Gutalagen Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Gut-specific homing ： ウィキペディア英語版 Gut-specific homing Gut-specific homing is the mechanism by which activated T cells and antibody-secreting cells (ASCs) are targeted to both inflamed and non-inflamed regions of the gut in order to provide an effective immune response. This process relies on the key interaction between the integrin α4β7 and the addressin MadCAM-1 on the surfaces of the appropriate cells. Additionally, this interaction is strengthened by the presence of CCR9, a chemokine receptor, which interacts with TECK. Vitamin A-derived retinoic acid regulates the expression of these cell surface proteins. ==T cell summary== T cells are produced in the thymus, and upon leaving they migrate to and around the lymphoid organs of the body, including lymph nodes. In the paracortex of the lymphoid nodes they are exposed to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). Specific interactions between the naïve T cells and their cognate antigens result in T cell activation. The activated T cells, immunoblasts, undergo clonal expansion before acquiring effector functions. The activated T cells then emigrate from the lymph nodes, via the efferent lymphatic vessel, and migrate around the body in the blood.〔 In certain circumstances, some activated T cells show a preference for patrolling certain tissues. This has been termed lymphocyte homing. Gut-specific homing is the term used to describe the preferential movement of activated T cells to the intestine and the gut. In this way T cells are effectively recruited to form part of the first line of defense against pathogens. This is because T cells are targeted to and recirculated around primary infection sites. Overall this results in an extremely high concentration of lymphocytes in this region; 70% of the immunoglobulin-producing cells are found in the mucosal surfaces of the body. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gut-specific homing」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.